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AccuGenomics presents their molecular standardization technology at GTCbio Molecular Diagnostic Conference in Boston, MA.

Posted on July 8, 2016

Dr. Tom Morrison, CSO of AccuGenomics, gave two presentations at the GTCbio Molecular Diagnostic Conference in Boston, MA July 6-8, 2016.  In his first talk, “Standardized Next Generation Sequencing Abundance Measurements (StarSeq) using Competitive Template Mixtures,” Dr. Morrison describes how the use of AccuGenomics’ competitive mixtures can enable highly multiplex and accurate digital PCR on Next Generation Sequencing Platforms (NGS).  “dPCR accuracy derives from the power of counting every target in a sample but has limited target throughput due florescent based detection schemes, whereas NGS has incredible multiplex throughput but limited accuracy due to library construction artifacts,” says Dr. Morrison.  The addition of competitive template mixtures to NGS provides the counting accuracy of dPCR while benefiting from the NGS throughput.”

Dr. Morrison’s second talk described AccuGenomics’ standardized qPCR technology and results from their SNAQ BCR-ABL1 pilot study.  Standardized Nucleic Acid Quantification (SNAQ) combines competitive mixtures and ratiometric measurements to eliminate the bias and errors that affect real-time qPCR abundance measurements.  “SNAQ ensures that every abundance measurement is the same between laboratories, instruments, reagent lots and time while providing comprehensive QA metrics not possible with real-time or dPCR platforms,” says Dr. Morrison.

NGS slide deck

qPCR slide deck

About GTCbio

GTCbio is a leading information center that provides quality forums, which facilitate the exchange of biopharmaceutical and biomedical intelligence between industry leaders, academic and government organizations, and the financial community. GTCbio conferences cover a variety of topics, such as stem cell therapeutics, infectious diseases, biotech partnering, pharmaceutical litigation, government regulation, bio-based chemicals and many more. Founded in 2002, GTCbio stimulates scientific discussions, offers key business insights, and promotes partnering and deal-making in the ever-changing biotech and pharmaceutical world.

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